PBP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91031-50, BS91031-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P30086(Human) P70296(Mouse) P31044(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat, zebrafish

Applications: WB, ICC/IF, IHC, IP,

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a(lpha)-chemokine family, resides in the a(lpha)-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PBP polyclonal antibody detects endogenous levels of PBP protein.

Bioworld Molecular Weight: 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PBP on mouse brain lysates using anti-PBP antibody at 1/1,000 dilution., ICC staining PBP in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: PEBP-1, RKIP, HCNP, Epididymis luminal protein 210, Epididymis secretory protein Li 34, Epididymis secretory protein Li 96, HCNP, HCNPpp, HEL 210, HEL S 34, HEL S 96, Hippocampal cholinergic neurostimulating peptide, Neuropolypeptide h3, PBP, PEBP, PEBP 1, PEBP-1, Pebp1, PEBP1, Phosphatidylethanolamine binding protein, Phosphatidylethanolamine binding protein 1, Prostatic binding protein, Prostatic-binding protein, R kip, Raf kinase inhibitor protein, Raf kinase inhibitory protein, RKIP,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified