Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

Product information

CAS Number: 1359993-59-1

Molecular Weight: 593.89

Formula: C36H59N5O2

Chemical Name: N-[4-({4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl}oxy)butyl]octadecanamide

Smiles: CCCCC1=NC2C(N)=NC3=CC=CC=C3C=2N1OCCCCNC(=O)CCCCCCCCCCCCCCCCC

InChiKey: RRTPWQXEERTRRK-UHFFFAOYSA-N

InChi: InChI=1S/C36H59N5O2/c1-3-5-7-8-9-10-11-12-13-14-15-16-17-18-19-27-33(42)38-28-22-23-29-43-41-32(26-6-4-2)40-34-35(41)30-24-20-21-25-31(30)39-36(34)37/h20-21,24-25H,3-19,22-23,26-29H2,1-2H3,(H2,37,39)(H,38,42)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (105.24 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

In Vivo:

Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors.

Products are for research use only. Not for human use.